Designing Selective SIK2 Inhibitors for Dual Anti-Inflammatory and Pro-Repair Effect

Inflammatory bowel disease and other chronic inflammatory diseases remain challenging to treat, in part because durable benefit may require more than suppression of pro-inflammatory signaling alone. Emerging biology suggests that salt-inducible kinase 2 (SIK2) sits at a key node of innate immune activation and tissue repair, making it an attractive target for diseases such as ulcerative colitis.