Nimbus Therapeutics Appoints Nathalie Franchimont, M.D., Ph.D., as Chief Medical Officer

CAMBRIDGE, Mass. – October 26, 2022 – Nimbus Therapeutics, a clinical-stage company that designs and develops breakthrough medicines through its powerful computational drug discovery engine, today announced the appointment of Nathalie Franchimont, M.D., Ph.D., as Chief Medical Officer.

“I am delighted to welcome Nathalie to our leadership team as Nimbus advances multiple potential breakthrough candidates into their next phase of development, including our clinical TYK2 and HPK1 inhibitors,” said Jeb Keiper, M.S., MBA, Chief Executive Officer of Nimbus. “Nathalie’s strategic leadership and extensive clinical experience will be an asset to our growing clinical development team, and her wide range of experience in the development and commercialization of both small and large molecules in various therapeutic areas is an ideal fit for the breadth of Nimbus’ pipeline.”

Dr. Franchimont joins Nimbus from Biogen, where she served as Senior Vice President, Head of Multiple Sclerosis and Immunology Development Unit. She previously held a variety of other leadership roles at Biogen, including leading the Multiple Sclerosis Research and Early Development Unit, the New Indications Research and Early Development Unit and the Immunology Drug Innovation Unit. Prior to joining Biogen, Dr. Franchimont held Medical Affairs and Clinical Development roles at Amgen. A rheumatologist by background, Dr. Franchimont trained at the University of Liège and has held research fellow and research associate roles at the University of Connecticut School of Medicine, Yale University School of Medicine and University of Liège. Dr. Franchimont has served on the Board of Directors of OMass Therapeutics since 2020.

“I am incredibly pleased to join Nimbus at a very exciting time in the company’s history and work with this accomplished team to bring new treatment possibilities to patients,” said Dr. Franchimont. “Nimbus has advanced compelling medicines targeting TYK2 and HPK1 to the clinic and is developing strategies to address multiple other highly sought-after targets. NDI-034858, in ongoing Phase 2b trials, is a great example of the power of Nimbus’ approach and I believe it has potential to be a differentiated, best-in-class oral allosteric TYK2 inhibitor for the treatment of psoriasis, psoriatic arthritis and other immune-mediated diseases.”

About Nimbus Therapeutics

Nimbus Therapeutics is a clinical-stage, structure-based drug discovery company developing novel small molecule medicines designed to act against well-validated but difficult-to-drug targets implicated in multiple human diseases. Nimbus combines leading-edge computational technologies with a tailored array of machine learning-based predictive modeling approaches. Nimbus has designed, discovered and developed a diverse portfolio of clinical and preclinical programs focused on inflammatory and autoimmune disorders, cancer and metabolic diseases, including three internally discovered compounds that have advanced into clinical trials. Nimbus is headquartered in Cambridge, MA. To learn more about Nimbus, please visit www.nimbustx.com.

 Media Contact

Chris Railey, (617) 834-0936
Ten Bridge Communications
chris@tenbridgecommunications.com

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Nimbus Therapeutics Announces Research Collaboration and License Agreement with Lilly for Small Molecule Activators of AMPK

Nimbus eligible to receive up to $496 million, inclusive of research funding and potential milestone payments, in addition to royalties on net sales

AMPK activation is a promising strategy to treat disorders of dysregulated metabolism

CAMBRIDGE, Mass. – October 11, 2022 – Nimbus Therapeutics, a clinical-stage company that is working to design and develop breakthrough medicines through its powerful computational drug discovery engine, today announced it has entered into a research collaboration and exclusive, worldwide license agreement with Eli Lilly and Company (Lilly) for the development and commercialization of novel targeted therapies that activate a specific isoform of AMPK for the treatment of metabolic diseases.

Leveraging Nimbus’s computational drug discovery engine and expertise in structure-based drug design, Nimbus is uniquely positioned to develop isoform-selective small molecule activators of AMPK with potential therapeutic application to a broad range of metabolic disorders.

“AMPK is a high-value target for the treatment of metabolic diseases, and drug developers have faced challenges for many years in identifying isoform-selective AMPK activators for tissue-specific therapeutic interventions. Nimbus has established a successful track record in developing and progressing highly-selective small molecules to the clinic against hard-to-interrogate targets, which is a demonstration of the power of our computational and structural approach to drug discovery,” said Peter Tummino, Ph.D., Chief Scientific Officer at Nimbus. “We are excited to partner with Lilly and benefit from their deep expertise in metabolic diseases, including diabetes, obesity and related disorders.”

“We look forward to collaborating with this innovative team at Nimbus, which has an established record of developing highly-specific small molecule modulators against important therapeutic targets,” said Ruth Gimeno, Ph.D., Lilly’s Senior Vice President, Diabetes Research and Clinical Investigation. “Developing therapies together that target AMPK helps address a critical need and is part of Lilly’s ongoing efforts to expand treatment options available to patients with metabolic disorders.”

Under the collaboration, Nimbus will be responsible for research activities, and Lilly will be responsible for development and commercialization activities worldwide. Financial consideration for Nimbus includes a series of payments, funding and milestones spread through research, development and commercialization, potentially reaching up to $496 million in total. Nimbus is eligible to receive tiered royalties on global net sales ranging from mid single- to low double-digits.

About Nimbus Therapeutics

Nimbus Therapeutics is a clinical-stage company working to design and develop breakthrough medicines through its powerful and comprehensive computational drug discovery engine. Nimbus’ pipeline is comprised of multiple selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and have proven difficult for drug makers to tackle. Nimbus is headquartered in Cambridge, MA. To learn more about Nimbus, please visit www.nimbustx.com.

Media Contacts:

Chris Railey, (617) 834-0936
Ten Bridge Communications

chris@tenbridgecommunications.com

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