Senior Director, Translational Medicine

Nimbus has an outstanding opportunity for an exceptional translational scientist with experience in clinical development in the fields of oncology, immuno-oncology, and/or immunology to join our team. The Senior Director of Translational Medicine will report to our Head of Translational Medicine.

In this role, you will:

  • Lead efforts to develop and implement strategies for clinical biomarker testing, indication assessment and expansion, patient stratification, combination therapy, mechanism of action studies, and drug candidate differentiation
  • Identify pharmacodynamic assays for utility in pre-clinical and clinical setting; help define PK/PD/efficacy relationships and test patient selection strategies
  • Develop clinical biomarker testing strategies for clinical trials, collaborate with clinical team on all aspects of clinical assay development and operations, and communicate translational designs and findings with clinical investigators
  • Lead primary analyses of pre-clinical and clinical exploratory translational biomarker studies
  • Author and review the translational sections of regulatory documents as well as scientific/clinical publications, and represent Nimbus Therapeutics to present translational findings at scientific congresses and investigator meetings
  • Manage relationships and scientific studies with diverse CRO’s, external collaborations with KOLs, and clinical investigators aimed at gaining a deeper understanding of MOA and the development of patient stratification or pharmacodynamic biomarkers
  • Contribute to early development of the Nimbus discovery pipeline as a Translational Medicine team representative for novel target programs and/or new target identification efforts
  • Additional responsibilities as needed and directed

These qualifications will help this role be successful:

Required qualifications:

  • Ph.D. in biochemistry, cell biology, bioinformatics, pharmacology, medical science, or related field
  • 8+ years of drug development experience in industry, including direct contributions to clinical and discovery drug development programs
  • Experienced leading biomarker testing in clinical trials for oncology and/or immunology drug development, including analysis of genome-wide ‘omics datasets
  • Outstanding track record of scientific achievement and excellent soft skills
  • Excellent verbal and written communication and organizational skills with demonstrated success in leading projects and interacting with cross functional teams
  • Ability to navigate, problem-solve, execute, and lead in a dynamic, fast-paced and evolving environment

Additional preferred qualifications include:

  • Experience in managing scientific teams and research in an externalized setting
  • Experience with small molecule drug development and IND submissions

A Snapshot of Nimbus 

Our Science  

At Nimbus, we design breakthrough medicines. Utilizing our powerful structure-based drug discovery engine, we create potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. With a decade-plus track record of success, we’ve built a world-class team in both computationally driven drug discovery and early clinical development while continuing to move the needle for patients.  

Our Culture 

Nimbus is a close-knit company (our employees are Nimbi, if you are curious!) that values a fast-paced, entrepreneurial, intellectual-stimulating, and collaborative environment. We live by our Core Values: Integrity, a Passion for Excellence, Teamwork, and Authentic Communication and strive to build a community where we bring out the best in each other professionally and personally.  

Our Company 

Founded in 2009, Nimbus is a private, growing biotechnology company headquartered in Cambridge, Massachusetts. Learn more about us by going to 

Join Nimbus. We are making a difference and you can too. 

At Nimbus, we believe our diversity of backgrounds and experiences strengthens our community and our ability to design breakthrough medicines. We prioritize creating an inclusive, welcoming culture that promotes our core values and encourages every Nimbi to bring their whole selves to their work. Nimbus is proud to be an equal opportunity employer. We value and celebrate all our employees and recognize that our diversity and inclusion are keys to our success. Nimbus is committed to providing equal opportunity for all employees and applicants without regard to race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Nimbus does not accept unsolicited resumes from any source other than directly from candidates.


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