Director of Computational Chemistry
Reporting to the Senior Vice President, Chemistry, the Director of Computational Chemistry will be working within multi-disciplinary teams to apply computational chemistry techniques, cheminformatics and molecular modeling to advance small-molecule drug discovery programs. The Director of Computational Chemistry needs to be creative, detail-oriented and a problem solver with a passion for drug discovery. The successful candidate must have a track record of applying computational chemistry and cheminformatics methods to solve problems at all stages of the drug discovery and development process.
More specifically, the Director of Computational Chemistry will:
- Apply structure-based and ligand-based drug design methodology to drive project initiation and progression
- Make key intellectual contributions to the direction of our in-house research programs
- Work closely with discovery scientists to inform, influence and prioritize their synthetic chemistry
- Design and optimize drug candidates using advanced computational techniques such as protein modeling, molecular docking based on X-ray or homology models, ligand-based design, library design, diversity analysis, conformational analysis and pharmacophore modeling
- Identify and implement new computational chemistry and molecule modeling methods and apply them in our drug discovery and development process
The qualifications we are seeking
- Ph.D. in computational chemistry, chemistry, biochemistry, biophysics or a related scientific field with a computational focus, plus 8+ years of industry experience
- Demonstrated track record of applying in silico techniques to drive drug discovery projects or impacting hit finding activities in drug discovery
- A comprehensive understanding of data mining and visualization, ligand and structure-based design, conformational analysis and pharmacophore optimization
- Demonstrated understanding of all aspects of modern drug discovery including medicinal chemistry, DMPK principles and multi-parameter optimization
- Demonstrated experience functioning within strong multi-disciplinary project teams
- Demonstrated experience in complex problem solving through in-depth analysis of data
- Extensive experience with scientific software such as Schrödinger, MOE, Pipeline Pilot, Spotfire, Discovery Studio, etc. Programming experience is a plus.
A snapshot of Nimbus
Nimbus is a biotechnology company located in the thriving biotech hub of Cambridge, Massachusetts. We transform drug development by integrating computational drug discovery techniques, a cutting-edge computational chemistry platform and other advanced technologies to design breakthrough medicines for patients.
We focus on promising targets in metabolic disease, oncology and inflammation. These include both emerging and well-validated targets that have proven intractable to others in the pharmaceutical and biotechnology industry.
Nimbus offers a fast-paced, entrepreneurial, team-focused work environment. The culture is intellectually stimulating, flexible and results-oriented. Joining our team of 30+ people offers significant opportunities to grow professionally and personally.
We also offer a top-notch benefits package (health, dental, life, vacation, and employer 401K contribution). Being part of Nimbus (a Nimbi, if you’re curious), allows you to become part of a small close-knit professional team that strives to bring out the best in each other by working hard and having fun together (company lunches and outings, running, rocking and even bowling from time to time!)